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ARTICLES
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1115-1122
| Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine
Iwan J. P. De Esch,
Roeland C. Vollinga,
Kees Goubitz,
Henk Schenk,
Ulf Appelberg,
Uli Hacksell,
Sylvia Lemstra,
Obbe P. Zuiderveld,
Marcel Hoffmann,
Rob Leurs,
Wiro M. P. B. Menge, and
Henk Timmerman
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1123-1144
| Piperazine Imidazo[1,5-a]quinoxaline Ureas as High-Affinity GABAA Ligands of Dual Functionality
E. Jon Jacobsen,
Lindsay S. Stelzer,
Ruth E. TenBrink,
Kenneth L. Belonga,
Donald B. Carter,
Haesook K. Im,
Wha Bin Im,
Vimala H. Sethy,
Andy H. Tang,
Philip F. VonVoigtlander,
James D. Petke,
Wei-Zhu Zhong, and
John W. Mickelson
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1145-1150
| Novel Potential Agents for Human Cytomegalovirus Infection: Synthesis and Antiviral Activity Evaluation of Benzothiadiazine Dioxide Acyclonucleosides
Ana Martinez,
Ana I. Esteban,
Ana Castro,
Carmen Gil,
Santiago Conde,
Graciela Andrei,
Robert Snoeck,
Jan Balzarini, and
Erik De Clercq
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1151-1160
| Synthesis, Structure-Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series
Yuntao Song,
David T. Connor,
Robert Doubleday,
Roderick J. Sorenson,
Anthony D. Sercel,
Paul C. Unangst,
Bruce D. Roth,
Richard B. Gilbertsen,
Kam Chan,
Denis J. Schrier,
Antonio Guglietta,
Dirk A. Bornemeier, and
Richard D. Dyer
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1161-1169
| Synthesis, Structure-Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series
Yuntao Song,
David T. Connor,
Anthony D. Sercel,
Roderick J. Sorenson,
Robert Doubleday,
Paul C. Unangst,
Bruce D. Roth,
Vlad G. Beylin,
Richard B. Gilbertsen,
Kam Chan,
Denis J. Schrier,
Antonio Guglietta,
Dirk A. Bornemeier, and
Richard D. Dyer
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1170-1177
| Design and Synthesis of a Potent Cyclic Analogue of the Myelin Basic Protein Epitope MBP72-85: Importance of the Ala81 Carboxyl Group and of a Cyclic Conformation for Induction of Experimental Allergic Encephalomyelitis
Theodore Tselios,
Lesley Probert,
Ioanna Daliani,
Elizabeth Matsoukas,
Anastasios Troganis,
Ioannis P. Gerothanassis,
Thomas Mavromoustakos,
Graham J. Moore, and
John M. Matsoukas
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1178-1192
| Orally Active Isoxazoline Glycoprotein IIb/IIIa Antagonists with Extended Duration of Action
Richard E. Olson,
Thais M. Sielecki,
John Wityak,
Donald J. Pinto,
Douglas G. Batt,
William E. Frietze,
Jie Liu,
A. Ewa Tobin,
Michael J. Orwat,
Susan V. Di Meo,
Gregory C. Houghton,
George K. Lalka,
Shaker A. Mousa,
Adrienne L. Racanelli,
Elizabeth A. Hausner,
Ram P. Kapil,
Shelley R. Rabel,
Martin J. Thoolen,
Thomas M. Reilly,
Paul S. Anderson, and
Ruth R. Wexler
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1193-1202
| Synthesis and in Vitro Pharmacology of a Series of New Chiral Histamine H3-Receptor Ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl Ether Derivatives
Jari T. Kovalainen,
Johannes A. M. Christiaans,
Sanna Kotisaari,
Jarmo T. Laitinen,
Pekka T. Männistö,
Leena Tuomisto, and
Jukka Gynther
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1203-1212
| Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure-Activity Studies of Ketomethylene-Containing Peptidomimetics
Peter S. Dragovich,
Thomas J. Prins,
Ru Zhou,
Shella A. Fuhrman,
Amy K. Patick,
David A. Matthews,
Clifford E. Ford,
James W. Meador III,
Rose Ann Ferre, and
Stephen T. Worland
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1213-1224
| Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as L-Glutamine Replacements
Peter S. Dragovich,
Thomas J. Prins,
Ru Zhou,
Stephen E. Webber,
Joseph T. Marakovits,
Shella A. Fuhrman,
Amy K. Patick,
David A. Matthews,
Caroline A. Lee,
Clifford E. Ford,
Benjamin J. Burke,
Paul A. Rejto,
Thomas F. Hendrickson,
Tove Tuntland,
Edward L. Brown,
James W. Meador III,
Rose Ann Ferre,
James E. V. Harr,
Maha B. Kosa, and
Stephen T. Worland
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1225-1234
| Binding Preferences of Hydroxamate Inhibitors of the Matrix Metalloproteinase Human Fibroblast Collagenase
Samuel Toba,
K. V. Damodaran, and
Kenneth M. Merz, Jr.
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1235-1249
| Guanidine Derivatives as Combined Thromboxane A2 Receptor Antagonists and Synthase Inhibitors
Rainer Soyka,
Brian D. Guth,
Hans M. Weisenberger,
Peter Luger, and
Thomas H. Müller
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1250-1261
| Docking of Cationic Antibiotics to Negatively Charged Pockets in RNA Folds
Thomas Hermann and
Eric Westhof
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1262-1273
| Enzyme-Assisted Total Synthesis of the Optical Antipodes D-myo-Inositol 3,4,5-Trisphosphate and D-myo-Inositol 1,5,6-Trisphosphate: Aspects of Their Structure-Activity Relationship to Biologically Active Inositol Phosphates
Stephan Adelt,
Oliver Plettenburg,
Rolf Stricker,
Georg Reiser,
Hans-Josef Altenbach, and
Günter Vogel
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1274-1281
| 2,3-Diarylcyclopentenones as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors
W. Cameron Black,
Christine Brideau,
Chi-Chung Chan,
Stella Charleson,
Nathalie Chauret,
David Claveau,
Diane Ethier,
Robert Gordon,
Gillian Greig,
Jocelyne Guay,
Gregory Hughes,
Paule Jolicoeur,
Yves Leblanc,
Deborah Nicoll-Griffith,
Nathalie Ouimet,
Denis Riendeau,
Denise Visco,
Zhaoyin Wang,
Lijing Xu, and
Petpiboon Prasit
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1282-1292
| Synthesis and Biological Evaluation of Boron-Containing Polyamines as Potential Agents for Neutron Capture Therapy of Brain Tumors
Jin-Cong Zhuo,
Jianping Cai,
Albert H. Soloway,
Rolf F. Barth,
Dianne M. Adams,
Weihua Ji, and
Werner Tjarks
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1293-1305
| 1-Arylnaphthalene Lignan: A Novel Scaffold for Type 5 Phosphodiesterase Inhibitor
Tatsuzo Ukita,
Yoshinori Nakamura,
Akira Kubo,
Yasuo Yamamoto,
Masami Takahashi,
Jun Kotera, and
Tomohiro Ikeo
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1306-1311
| Quinuclidine Inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase: Optimization from Lipid Profiles
George R. Brown,
David M. Hollinshead,
Elaine S. E. Stokes,
David S. Clarke,
M. Allan Eakin,
Alan J. Foubister,
Steven C. Glossop,
David Griffiths,
Michael C. Johnson,
Fergus McTaggart,
Donald J. Mirrlees,
Graham J. Smith, and
Robin Wood
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1312-1319
| Fluorescent Pseudo-Peptide Linear Vasopressin Antagonists: Design, Synthesis, and Applications
Thierry Durroux,
Marion Peter,
Gerardo Turcatti,
André Chollet,
Marie-Noëlle Balestre,
Claude Barberis, and
René Seyer
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1320-1328
| Synthesis and Anti-HIV and Anti-HBV Activities of 2'-Fluoro-2',3'-unsaturated L-Nucleosides
Kyeong Lee,
Yongseok Choi,
Elizabeth Gullen,
Susan Schlueter-Wirtz,
Raymond F. Schinazi,
Yung-Chi Cheng, and
Chung K. Chu
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